PRP Hair Restoration is a series of injections of PRP (Platelet Rich Plasma) into the scalp, which has been clinically proven to rejuvenate weakened hair follicles. This rejuvenation process can stimulate regrowth of thinning hair, increase hair growth, and grow your hair thicker and stronger.
PRP Hair Restoration s a PRP (Platelet Rich Plasma) injection into several places in the scalp, to help stimulate new hair growth and firm and repair existing hair follicles. The treatment includes drawing the patient’s own blood, spinning it to separate the plasma, and injecting that plasma into the scalp.
What is A-PRP ® ?
Platelets are key factors in hard and soft tissue repair mechanisms.
They provide the essential growth factors FGF, PDGF, TGF-ß, EGF, VEGF, and IGF that are involved in stem cell migration, differentiation, and proliferation. The stimulation of fibroblasts and endothelial cells induces new extracellular matrix deposition and neovascularization.
Plasma is essential for cell survival as it contains nutrients, vitamins, hormones, electrolytes, and proteins. Proteins are key molecules for the coagulation process and the formation of the fibrin polymer that will serve as a scaffold for cell migration, differentiation, and proliferation.
How Does PRP Work?
Human blood contains mesenchymal stem cells, and autologous blood products that contain essential and specific growth factors that assist in tissue regeneration and healing. Published medical literature from Europe and the United States confirms the safety and use of PRP therapy. It has been used as a medial adjunct therapy for over two decades for skin and wound healing. PRP therapy has established itself to be effective as a medical treatment modality in the specialty fields of oral surgery, neurosurgery, plastic and cosmetic surgery, sports medicine and orthopedics. It has been used extensively in these specialties for the last twenty years with generally positive outcomes and success. In the field of hair restoration, evidence supports PRP therapy as a promising treatment option to promote hair growth. No claim can be made of its efficacy. But it is a promising non-surgical therapeutic option for those patients with hair loss.
How Do You Perform The Procedure?
Blood is drawn in our office as though you are having routine blood testing at your primary care physician’s office. The blood is spun in a centrifuge and the PRP is separated and removed from the rest of the blood.
The PRP is taken from your body and is specially prepared by spinning down the blood cells to a high concentration. We use the Eclipse Gold PRP System. It is a closed sterile system and the platelets are concentrated to 3X the normal blood values. The system eliminates granulocytes which hurt tissue regeneration and wound healing. The highly concentrated platelet-rich plasma (PRP) is then injected into the scalp. The patient’s hair is then cleansed and the patient may drive home without any assistance. No sedation or any medication is given during the procedure to inhibit the ability to drive or use machinery.
The Science Of PRP
PRP contains special cells called Platelets, that can theoretically cause the growth of the hair follicles by stimulating the stem cells and other cells in the microenvironment of the hair follicle. These special Platelet cells promote healing, accelerates the rate and degree of tissue healing and regeneration, respond to injury, and formation of new cellular growth. The primary purpose of using PRP in hair restoration is to stimulate inactive or newly implanted hair follicles into an active growth phase.
Inside the Platelets are many intracellular structures such as glycogen, lysosomes, and alpha granules. These granules within the PRP contain clotting and growth factors that are eventually released during the healing and repair process.
Ideal Platelet Concentration
The Regen™-BCT tube prepares 5 to 6 ml of autologous platelet-rich plasma with a platelet recovery greater than 80% and a concentration factor of 1.6-fold. Although the system is technically capable of producing significantly higher platelet concentrations, it is not what some research shows to be the most beneficial for clinical use. More and more studies demonstrate that concentrations of platelets 1 to 3 times over the baseline show more robust healing rates than those with concentrations of 3 to 8 times the baseline.
Some studies even showed that too high platelet concentrations may actually have negative effects. In an in vivo study, it was shown that highly concentrated platelet preparations had an inhibitory influence on osteoblast activity, probably due to unwanted inhibitory and cytotoxic effects of growth factors at such high concentrations. Similarly, an in vitro study demonstrated that platelet concentrations over 2.5-fold resulted in a reduction in proliferation and a suboptimal effect on osteoblast function.
White Blood Cells In Tissue Regeneration
White blood cells are strongly reduced (> 85% depletion) with the Regen™ PRP® system. The role of white blood cells (WBC) in healing is controversially discussed among physicians. To address this concern scientifically, WBC subsets, granulocytes, and mononuclear cells need to be looked at individually. Granulocytes, and more specifically neutrophils, are the front-line defenders against invading pathogens and are associated with the inflammatory response. They release a large variety of highly active antimicrobial substances and proteases. Uncontrolled release of these factors can cause severe damage to the tissue, delay healing rates and increase the risk of scarring. Thanks to the Regen™ PRP® system, more than 96% of the granulocytes are removed from autologous platelet-rich plasma. The few white blood cells still present in autologous platelet-rich plasma are mostly mononuclear cells (lymphocytes and
monocytes). These two cell types are also involved in the immune response but have also been shown to support the healing process.